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6558

FEATURED GIG

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CYSTIC FIBROSIS BENEFIT

Kalamazoo, Michigan

WHERE? Kraftbrau Brewery - 402 East Kalamazoo Avenue - Kalamazoo, Michigan - 269-384-0288
WHEN? Sunday, March 16, 2003 - doors open at 7:00 pm - show begins around 8:00
WHO? Opening act - SHRUMP / Headliner - ZAMBONIE
WHY? To raise money for the Cystic Fibrosis Foundation. 100% of the door will go to this worthy cause.
HOW MUCH? Only five bucks to get in - but think about dropping them a buck or two more, eh?
You must be 18 to attend this show.

Read about CF below.

Listen to 103.3 WKFR on Wednesday, March 12, 2003 to hear a special acoustic version of "Anna's Song" - written for Zambonie members Erik and Kent's cousin who died last year from CF.

NEED DIRECTIONS?

DIRECTIONS DIRECT FROM THE CLUB

Got a benefit coming up? Send us an e-mail at:
featured.gig@guitarclub.indiegroup.com
and we'll try to post it quickly.

ABOUT CYSTIC FIBROSIS

Cystic fibrosis is a hereditary disease that causes certain glands to produce abnormal secretions, resulting in several symptoms, the most important of which affect the digestive tract and the lungs.

Cystic fibrosis is the most common inherited disease leading to death among white people in the United States. It occurs in 1 of every 2,500 white babies and in 1 of every 17,000 black babies. It's rare in Asians. Cystic fibrosis is equally common in boys and girls. Many people with cystic fibrosis die young, but 35 percent of Americans with cystic fibrosis reach adulthood.

About 5 percent of white people carry one defective gene responsible for cystic fibrosis, but the trait is recessive, and the disease develops only if a person has two defective genes. (see illustration, page 10) People with only one defective gene have no noticeable symptoms. The gene controls the production of a protein that regulates the transfer of chloride and sodium (salt) across cell membranes. When both genes are abnormal, chloride and sodium transfer is disrupted, leading to dehydration and increased stickiness of secretions.

Cystic fibrosis affects nearly all the exocrine glands (glands that secrete fluids into a duct). The secretions are abnormal in different ways, and they affect gland function. In some glands, such as the pancreas and those in the intestines, the secretions are thick or solid and may block the gland completely. The mucus-producing glands in the airways of the lungs produce abnormal secretions that clog the airways and allow bacteria to multiply. The sweat glands, parotid glands, and small salivary glands secrete fluids containing more salt than normal.*

PROGNOSIS

The severity of cystic fibrosis varies greatly from person to person regardless of age; the severity is determined largely by how much the lungs are affected. However, deterioration is inevitable, leading to debility and eventually death. Nonetheless, the outlook has improved steadily over the past 25 years, mainly because treatments can now postpone some of the changes that occur in the lungs. Half of the people with cystic fibrosis live longer than 28 years. Long-term survival is somewhat better in males, people who don't have pancreatic problems, and people whose initial symptoms are restricted to the digestive system. Despite their many problems, people with cystic fibrosis usually attend school or work until shortly before death. Gene therapy holds great promise for treating cystic fibrosis.

Surgery may be needed for the collapse of a lung segment (pneumothorax), a chronic sinus infection, severe chronic infection in one area of the lung, bleeding from blood vessels in the esophagus, gallbladder disease, or obstruction of the intestine. Liver transplantation has been successful for severe liver damage. Transplantation of a heart and two lungs is being performed for severe heart and lung disease. These types of transplantation are becoming more routine and more successful with experience and improved techniques. One year after transplantation, about 75 percent of patients are alive, and their condition is much improved.

People with cystic fibrosis usually die of respiratory failure after many years of deteriorating lung function. A small number, however, die of liver disease, bleeding into the airway, or complications of surgery.*

*Information gathered from The Merck Manual

For more information go to:

www.cff.org

www.cysticfibrosis.com